Science
Regeneration instead of filling.
Fillers add volume from outside. Regenerative technologies signal the skin to restore its own hydration, collagen and density. Here is how each one works.
One principle, three paths
With age, fibroblasts slow down, collagen and hyaluronic acid decline, and skin loses water, density and elasticity. Regenerative aesthetics doesn’t replace what was lost; it restores the processes that make it.
Comparison
| PolynucleotidesAmeela Face · Eyes · Rejuvenation | PDRN + exosomesAmeela Exosomes | PDO microspheresUltracol 100 · 200 | |
|---|---|---|---|
| Origin | Wild salmon DNA | Salmon DNA + grapefruit and watermelon | Polydioxanone (PDO), a surgical material |
| How it works | Binds water, activates fibroblasts (A2A) | Receptor signalling, cell communication | Controlled response → new type III → I collagen |
| Molecule / particle | > 1500 kDa | PDRN 50-1500 kDa | 10-50 µm · 30-110 µm |
| Application | Intradermal, 30-32G, 1-2 mm | Microneedling, mesotherapy | Needle (100) · cannula (200) |
| Course | 2-3 sessions, 2-3 weeks apart | 3-4 sessions, 2-3 weeks apart | At the doctor’s discretion |
| Maintenance | every 6-9 months | 1-2 every 6-9 months | every 6-12 months |
| Strongest at | Hydration, density, delicate areas | Glow, texture, recovery | Collagen, volume, contour |
This information is for healthcare professionals and does not replace the instructions for use.
Glossary
- PN
- Polynucleotides: long DNA chains that hydrate and build a scaffold in the dermis.
- PDRN
- Polydeoxyribonucleotides: shorter DNA fragments that act as a signal through A2A receptors.
- Exosomes
- Microscopic vesicles that cells use to exchange signals.
- PDO
- Polydioxanone: a surgical suture material used for decades, which breaks down into water and CO₂.
- A2A
- An adenosine receptor whose activation stimulates fibroblasts, angiogenesis and repair.
- Fibroblast
- The dermal cell that makes collagen, elastin and hyaluronic acid.
Remedy Technology
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